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Although the contribution of dietary methionine excess (which increases folate, vitamin B 6 , and vitamin B 12 requirements) has not been clinically assessed, folate deficiency (associated or not with the thermolabile MTHFR mutation) and vitamin B 6 deficiency (associated or not with heterozygosity for CBS defects) could largely account for this increased risk of hyperhomocysteinemia-related cardiovascular disease
The quality of clinical support at Found is generally rated well by patients, with particular praise for the medical expertise of the provider team
This is a nuanced clinical decision
Doses above 3 mg per day lack additional evidence of benefit and are not generally recommended
In conclusion, the STEP TEENS trial demonstrated the efficacy of once-weekly semaglutide 2.4 mg plus lifestyle intervention in reducing BMI when compared to lifestyle intervention only
