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The authors reported that semaglutide is metabolized via proteolytic cleavage of the peptide backbone and b-oxidation of the fatty acid side chain

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Many studies have found that reflux does not directly damage the esophageal epithelium, but stimulates the secretion of inflammatory chemokines by the epithelial cells, which induces proliferative changes in the epithelium and recruitment of inflammatory cells such as T lymphocytes, which in turn leads to the damage of the esophageal epithelium

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