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Properties: The drug is a combination of two hypoglycemic drugs with a complementary mechanism of action, designed to improve glycemic control in patients with type 2 diabetes mellitus: sitagliptin, an inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4), and metformin, a representative of the biguanide class
Annu Rev Pharmacol Toxicol 64:231253
Cultures were 8595% confluent on the day of the experiment
( F ) Paradigm for analyzing long-term chronic effects of chemogenetic activation of LS GLP-1R neurons on food intake and body weight
A refined definition of astrocyte reactivity includes four key features: (1) cellular, molecular and functional changes in response to CNS insults, (2) graded responses depending on insult severity, (3) context-dependent reactions influenced by intra- and intercellular signaling and (4) beneficial or detrimental effects on surrounding cells 35
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