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9 The HbA1c reduction was sustained as far out as 78 weeks (58% of patients) and 104 weeks (10% of patients)
How injectable/oral GLP-1 medications work: Mimic the GLP-1 hormone with engineered modifications for extended duration Bind to GLP-1 receptors to enhance insulin release and reduce glucagon Slow gastric emptying by 20-50%, promoting satiety Supported by large randomized controlled trialsthe STEP trials showed 14.9% mean weight loss at 68 weeks versus 2.4% for placebo The short answer on why patches cant deliver these drugs: GLP-1 molecules are relatively large peptide chains (molecular weight 3-5 kDa) that cannot effectively penetrate the skin barrier through passive transdermal diffusion
Tosatto SC, Bosello V, Fogolari F, Mauri P, Roveri A, Toppo S et al
A clinical review reduces the risk of restarting in a way that is unsuitable for your current circumstances
If your reaction doesnt go away, gets worse, or spreads, contact your healthcare provider to ensure youre not experiencing an infection or allergic reaction
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