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In addition, insulin administration is known to result in increased GST gene expression through the PI3K/AKT/mTOR pathway and reduced intracellular oxidative stress, while glucagon decreases such gene expression
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Finally, weight loss, even with the aid of GLP-1 medications, can be more challenging in a hormone-deficient state, including late perimenopause, menopause, and the postmenopausal years
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