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Nat Rev Neurosci 14(4):248264
Data availability The RNA-seq data generated in this study has been deposited in the Gene Expression Omnibus (GEO) database at NCBI under accession code GSE249592
They are particularly beneficial for vegetarians and vegans (since B12 is found primarily in animal products), older adults with reduced absorption capacity, individuals with digestive conditions such as Crohn's disease or celiac disease, and anyone who has had gastric bypass surgery
Although substances that increase energy expenditure have existed, their clinical use has been limited due to safety concerns
The manufacturer has set the cost of these medications extremely high, which makes it very expensive for patients, especially those without insurance
