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MariTide Name: Maridebart cafraglutide (MariTide, formerly AMG 133) Manufacturer: Amgen Current stage: US phase III trial currently underway (MARITIME, NCT06858839) Takeaway: The dual agonist/antagonist action of MariTide could promise higher weight loss with fewer side effects, with dosing at less frequent intervals but more studies are needed
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These effects on hypothalamic catecholamine regulation contribute to restoration of proper circadian signaling needed for reproductive hormone surges and metabolic timing
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Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines
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