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The clinical significance of the VMAT transporters is evidenced by the fact that variants in VMAT1 have been found to be associated with susceptibility for schizophrenia and bipolar depression
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ
In practice, many protocols do not treat this as an either/or decision at all, and instead combine the two mechanisms a point covered in the next section
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