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Pharmacies across the UK experienced shortages ahead of the hike, with wholesalers pausing orders to manage demand

Levothyroxine dosing is influenced by body weight, with typical maintenance doses ranging from 1.6-1.8 mcg/kg/day based on ideal or lean body weight (using actual body weight in obesity may lead to overreplacement)

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This is a well-established physiological response

Clinicians and patients should therefore maintain a low threshold for investigation, particularly in those with identifiable risk factors