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This requires: Rapid cell division (for skin cells, fibroblasts, and endothelial cells) Adequate oxygen delivery to the wound bed Collagen synthesis and cross-linking Immune function to prevent infection Vitamin B12 contributes directly to the first two of these, and indirectly to the others

Poor circulation limits oxygen delivery to nerves

A.GuanW.et al (2016)

For researchers designing Matrixyl vs GHK-Cu studies, the choice of endpoints profoundly affects protocol design

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