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Of the plethora of articles retrieved from the second MEDLINE search, we identified 28 systematic reviews of animal stud-ies, [39-41] GSH-related genetic polymorphisms linked to various cancers (colorectal can-cer, [42] leukaemia, [43,44] lung cancer,[ 45,46] bladder cancer, [47] gastric cancer, [48,49] prostate cancer, [50-53] adult brain tumours, [54] basal cell carcinoma [55] ) and linked to other disorders (autism, [12, 13] hypertension, 56,57 respiratory diseases, [58,59] cataract, [60] myelodysplastic syndrome, [61,62] glioma [63] and male idio-pathic infertility.[ 64] ) There were 9 RCTs identified from two systematic reviews of the use of GSH to reduce chemotherapy-induced toxicity (6 cisplatin, 2 axaliplatin, 1 platinum)

6e and Supplementary Fig

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Although methylcobalamin and vitamin B12 are terms used interchangeably, vitamin B12 is also available as hydroxocobalamin, a less commonly prescribed drug product (see Hydroxocobalamin monograph), and methylcobalamin

High-dose B12 seems promising, mainly for those with a B12 deficiency or at risk