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To examine the role of GSH precursor administration, NAC in the drinking water was given 4 hours after TNBS+ethanol administration and colonic tissue for evaluation of damage and GSH content was obtained at 24 hours post TNBS administration

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DEFENSE AGAINST ELECTROPHILES AND PROTEIN GLUTATHIONYLATION In addition to the defense against oxidants and ROS, GSH plays also an important role in the protection against electrophiles by glutathione- S -transferases (GSTs)

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