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The copper ion itself serves as a cofactor for lysyl oxidase, the enzyme responsible for collagen and elastin cross-linking, meaning GHK-Cu both stimulates production of new structural proteins and ensures they are properly stabilized

Cell proliferation was evaluated using a Promega CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) as per the manufacturers instructions (Promega G3580)

10.1126/sciadv.abq7032 189 OzbalS.ErbilG.KodorH.TuyanK.PeketinC.OzoulC

Most side effects are mild and manageable, but there are rare and more severe risks that should not be overlooked

Nuclear import of Insulin-like Growth Factor-binding Protein-3 and -5 is mediated by the importin