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Of particular note is a lack of neoplastic induction, since c-Met is recognized as an oncogene

Animal Model and Ethics Statement Wistar rats from the breeding colony at the Universidade do Extremo Sul Catarinense (UNESC), Brazil, were housed four times per cage under controlled conditions of temperature (22 1 C), relative humidity (4555%) and light-dark cycle (12:12 p.m., light on at 6 a.m.)

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In addition, IHC for VEGF-A (Proteintech, Chicago, IL, USA) and CD34 (Proteintech, Chicago, IL, USA) were performed using the automated IHC system (Hoffman La-Roche Ltd., Basel, Switzerland)

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