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While numerous proof-of-concept candidate molecules have been disclosed (3443), the only approved example of multi-receptor agonism for obesity and T2D is the dual GLP-1R/GIPR co-agonist tirzepatide (marketed as Mounjaro and Zepbound ) (34, 44)
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Unlike oral medications, injectable semaglutide can be administered irrespective of meals
Peptide therapy can also be discussed in this same signaling context, because targeted peptides may be used to support specific physiological pathways rather than to replace hormones directly
doi: 10.1016/j.jmb.2020.01.037, 61
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