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These weight reductions were associated with improvements in cardiometabolic risk factors and sustained effects over two years

Moreover, prolactinomas resistance to cabergoline has been associated with invasive and more aggressive tumors, and with the increased risk to develop a carcinoma ( Intensive investigations in the past years have discovered different molecular alterations possibly involved in this variable responsiveness to DA and SS, including defective expression or genetic alterations of DRD2 and SSTRs, alterations in their signaling pathways, and cytoskeleton proteins involvement (Figure 1) but much remains to be clarified about this complex phenomenon

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