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1 Roche has indicated that the Phase III clinical program for CT-388 in obesity, Enith1 and Enith2, is expected to begin in the first quarter of 2026

A recent study has reported that concurrent inhibition of endogenous antioxidant enzymes (e.g., glutathione biosynthesis) with enzymes involved in ROS production (e.g., NOX) may improve treatment outcomes (113)

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Compounded tirzepatide is most often supplied so that reconstitution produces a 5 mg/ml or 10 mg/ml working solution, not the 1 mg/ml semaglutide standard