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16% of Britons and 14% of Americans experienced improved digestion

The degree of loose skin varies based on age, total weight lost, rate of loss, genetics, and prior skin condition

The researchers concluded that most of these hormonal changes (particularly TSH and free T3) appeared to be independent of weight loss, suggesting a possible direct effect of semaglutide on thyroid regulation that still needs to be clarified, while changes in free T4 were more closely related to weight change