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The mice were intravenously administered with saline, LAAM GSH-CQDs, DOX, Doxil, or DOX/LAAM GSH-CQDs at a dose equivalent to 6 mg kg 1 DOX, or DOX/LAAM GSH-CQDs at a dose equivalent to 2 mg kg 1 DOX on days 0, 4, 8, and 12 ( n = 3)
In advanced AD, BBB alterations are marked by the progressive loss of TJ proteinsnamely, decreased expression of occludin, claudin-5, and ZO-1 [48, 49]
Elevated homocysteine levels (which rise when vitamin B12, folic acid, or vitamin B6 are low) have also been associated in observational studies with higher rates of Alzheimers disease and dementia
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