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5 Heatmap depicting relative levels (log fold change) of differentially expressed selected candidate genes associated with MASH and fibrosis in semaglutide-treated DIO-MASH mice (a) and CDA-HFD mice (b)
The bridge program covers three FDA-approved GLP-1 medications when used for chronic weight management: Wegovy (semaglutide injection and tablets), Zepbound (tirzepatide KwikPen), and Foundayo (orforglipron, the first oral GLP-1 pill for weight loss)
M Krajcovicov-Kudlckov, R Simoncic, A Bderov, K Babinsk, & I Bder
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In the adjusted cause-specific-hazard regression for the GLP-1 RA vs DPP-4 inhibitor cohort, GLP-1 RAs were associated with a lower risk of suicide or suicide attempts compared with DPP-4 inhibitors after 1 year follow-up (HR 365 0.58 [0.37;0.91])
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