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Coefficient of Variance Intra Variation% 10% Inter Variation% 12% Recovery 95-102% Linearity Diluent Ratio Range % 1:2 93-105 1:4 88-106 1:8 86-108 Specificity/Cross-reactivity No significant cross-reactivity or interference between GSH Px and analogues was observed

Intracellular reactive oxygen species production may cause cellular damage ( Reference Streck, Vieira and Wannmacher 9 ) and disorders of the antioxidant defence system ( Reference Blundell, Jones and Rose 12 ) , demonstrating a mechanistic connection between hyperhomocysteinaemia, oxidative stress and disease

Together, these metabolic alterations suggest a biochemical framework in which inflammation, oxidative stress, and TTR misfolding may be interconnected in TTR-V30M amyloidosis

Adjusting the dose for each patients needs is vital for safe and effective treatment