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To investigate the ability to generate a therapeutic effect, the multicellular tumor spheroids were treated with Ru(II)-OH, NP2, or NP4 (10 M Ru) in a 1% or 21% O 2 atmosphere and afterward incubated with a cell live or death stain
These two characteristics make it inherently unsuitable for standard topical delivery: it degrades before it absorbs, and it repels the lipid-rich skin barrier
It can interfere with daily activities and impair willingness to go out with friends, speaking in public, going to the pool, etc
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Unfortunately, however, veterinarians do not often administer drugs to normal, healthy animals
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