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Mitochondrial dysfunction from any cause (biotoxin illness, heavy metals, oxidative stress) directly impairs amino acid conjugation because the activation step requires mitochondrial ATP and CoA
They do not suit everyone, they only work while they are used, and finasteride is not suitable for women, so they are decisions to make with a clinician rather than choices to make from an article
Among studies on topical glutathione, a 0.5% concentration showed significantly greater reduction in pigmentation than both 0.1% and placebo
10.1016/j.bbr.2024.114934 49 GrootaertM
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