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Piperlongumine and its analogs were developed with the aim of increasing cellular ROS and inducing oxidative stress by blocking GSTP 32,33,34

The Dark Side: Glutathione and Chemoresistance While glutathione has protective effects, it can also contribute to cancer progression and treatment resistance: Elevated Levels in Tumors : Many cancer cells exhibit increased levels of glutathione, which can protect them from the cytotoxic effects of chemotherapy

It is called 'hydrated silica' because it is silica with extra bonded water atoms

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Its not safe during pregnancy and should be stopped well in advance of trying to conceive