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Early administration of lactate in rat organotypic hippocampal slices after oxygen-glucose deprivation protected against neuronal death, decreased lesion size and showed better neurologic outcomes in a mouse model of middle cerebral artery occlusion (Berthet et al., 2011), in mouse cortical neuron cultures (Jourdain et al., 2016) and in rat cortex in vivo (Ros et al., 2001)
GHK-Cu has the larger skin and wound-healing evidence base
This crucial interaction orchestrates neuronal differentiation, extensive dendritic branching, and heightened synaptic plasticity
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