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[1] Primary mechanisms: modulation of the nitric oxide (NO) system via upregulation of eNOS, activation of VEGFR2-Akt-eNOS signaling for angiogenesis, and enhancement of antioxidant defenses (HO-1 upregulation)

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Prescribing Requirements The authorized prescriber must be a physician identified on the TFA Rheumatology List of Authorized Prescribers maintained by the Ontario Rheumatology Association, which is responsible for determining prescriber eligibility

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