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A lack of vitamin B12 is treated with methylcobalamin

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If low levels of B 12 remain for a long time, the condition also can lead to irreversible damage to nerve cells, which can cause the following symptoms: numbness and tingling in the hands and feet difficulty walking muscle weakness irritability memory loss dementia depression psychosis

This bidirectional peripheral-central interaction generates a self-sustaining feedforward loop that couples immune dysregulation to progressive dopaminergic neuron loss