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P21 is a synthetic CNTF-derived peptide, modified with an adamantane group for stability

(6) When experimenting with the peptide, the investigators apparently recorded lower readings of biochemical markers associated with inflammation, among them indicators of neutrophil buildup, leukotriene B4, and thromboxane B2 within inflamed cell cultures

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Nausea (most common, especially during first 1 to 2 weeks of a new dose) Diarrhea or, just as often, constipation Vomiting (less common but more likely at 9 to 12 mg) Reduced appetite, food noise quieting down (this is the goal, not a side effect) Skin sensitivity (dysesthesia): tingling, prickly feeling, or sunburn-like skin

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