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As the dopamine-producing neurons in the substantia nigra are lost, the availability of therapeutic targets diminishes, while receptor desensitization and downregulation further impair drug effectiveness

A Non-Randomized, Open Label, Controlled, Dose-Escalation, Phase I Clinical Trial to Evaluate the Safety, Reactogenicity and Immunogenicity of One or Two Administrations of Candidate Rabies mRNA Vaccine CV7202 in Healthy Adult Subjects

In a retrospective cohort study of patients with type 2 diabetes, coadministration with serotonergic antidepressants (eg, citalopram/escitalopram) was associated with attenuation of the weight loss effects of GLP-1 agonists

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These advanced therapeutics hold the potential to revolutionize the management of metabolic disorders by providing sustained benefits for glucose control, weight loss, and overall metabolic health [80,81,82] (Table 1)