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The vast majority of side effects are GI-related, temporary, and manageable with the right approach

While most people want to lose weight as quickly as possible, its better for your body, bones and muscle to lose small amounts of weight over a longer period of time

Working with your prescriber to adjust any existing diabetes medications (metformin, insulin, sulfonylureas) when starting retatrutide prevents the dangerous hypoglycemia that causes extreme fatigue, confusion, and potentially serious complications

The American Diabetes Association (ADA) and American College of Cardiology (ACC) now recommend GLP-1 receptor agonists with proven cardiovascular benefit, including semaglutide, as preferred agents for patients with diabetes and atherosclerotic cardiovascular disease

It can also cause poor muscle metabolism and other negative health effects