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Both were discontinued in 2008 and approval was withdrawn effective 18 June 2009
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Thyroid Safety and Cancer Risk Concerns in Extended Use Animal studies of GLP-1 and GIP agonists revealed dose-dependent thyroid C-cell proliferation and increased risk of medullary thyroid carcinoma in rodents, which led to a black box warning on all GLP-1 medications
LBA 29 Johansen, N
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