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10.3390/biom12010056 131 van der PollT.van de VeerdonkF

Many clinicians and researchers extend the time at each dose level if side effects are bothersome

PD-1 deficiency may then result in an altered microbial composition characterized by increased Enterobacteriaceae and decreased Bifidobacterium abundances (52)

This suggests that starting with lower doses and smaller dose increments is associated with a more favorable side effect profile