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The product should not be used by children, pregnant women, and nursing mothers
This matters when considering dose-response relationships: a heavier subject at 8 mg may lose more kilograms than a lighter subject at 12 mg, even though the relative loss looks different on paper
Karger, 189-201, 2000
It can worsen GI side effects, particularly nausea and bloating
Interestingly, plasma mannose was significantly enriched in obese, insulin-resistant, and low insulin-secreting subjects, even more significantly than glucose
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