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The target pathway under investigation direct lipolysis, receptor-mediated signaling, or upstream hormone stimulation is typically the deciding factor in which compound class fits a given research design

While SURPASS-2 was not powered for ethnic subgroup comparisons on insulin sensitivity endpoints, the mechanism of action suggests that patients with higher baseline HOMA-IR (a common finding in Hispanic/Latino individuals) may see relatively larger absolute improvements in glycemic markers

To participate in the model, state Medicaid programs must sign a State Agreement with CMS and then adopt supplemental rebate agreements (SRAs) with each participating manufacturer that reflects the standard key terms that the participating manufacturers and CMS have agreed to

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