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[1] 5 kg/m less) apply for people from South Asian, Chinese, Black African, or African-Caribbean backgrounds A history of an eating disorder, as restrictive dietary approaches can be harmful and require specialist oversight Pregnancy, breastfeeding, or if you are under 18 or a frail older adult these groups should seek medical advice before making significant dietary changes Current use of medications associated with weight gain, where a review of prescribing may be warranted A GP can arrange relevant investigations such as thyroid function tests (TFTs), HbA1c or fasting plasma glucose, and a fasting lipid profile to identify any underlying conditions contributing to weight difficulties

The LEADER, SUSTAIN-6, and REWIND trials collectively demonstrate the cardiovascular outcome benefits of GLP-1 receptor agonists in people with type 2 diabetes and at high CVD risk

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