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As of 2023, no published randomised controlled trials specifically investigate GLP-1 receptor agonists as a treatment for ADHD

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When metabolic flexibility is restored: Hunger becomes more predictable Energy levels stabilize Fat loss occurs without persistent deprivation Weight becomes easier to maintain over time (25) This state cannot be achieved through calorie restriction alone

This vascular mechanism may help explain why GLP-1RAs consistently show reduced dementia incidence in large observational cohorts, even when effects on amyloid burden or short-term cognition are modest [13,14,15]

Some patients might need a slower dose escalation, while others can handle faster adjustments