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In 2019, liver-expressed antimicrobial peptide (LEAP2), initially discovered as an antimicrobial peptide produced in the liver, was identified to be upregulated in the stomach of diet-induced obese mice after vertical sleeve gastrectomy

Tirzepatide trials produced even better results, with the SURMOUNT-1 trial showing 15-22.5 percent body weight reduction depending on dose

UV signature mutations also emerged in late disease in 8 patients, likely derived from low abundance subpopulations in early disease that seeded distant metastases

This stage enhances patient outcomes and loyalty

These may include gastrointestinal issues, allergic reactions, or skin rashes