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In T2D mouse models, sex-specific differences in GPER expression were observed, with female mice exhibiting significantly higher levels of GPER expression than male mice, while GPER expression decreased significantly following the induction of diabetes, implying that GPER expression influences the occurrence and development of diabetes

No Serious Adverse Reactions in Short-Term DAC Studies In the major healthy-adult study of CJC-1295 with DAC, no serious adverse reactions were reported

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