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Chromatographic separation was performed using a Vanquish ultra high performance liquid chromatography (UHPLC) system with a column temperature of 40C, a flow rate of 0.2 mL/min, and the mobile phase consisting of A: 0.1% formic acid and B: methanol
A total of 1140 genes with 1146 UniProt IDs associated with epilepsy were obtained from the DisGeNET database
In addition to the PERK-ATF4-CHOP axis, other key ER stress pathways, such as IRE1/XBP1 and ATF6 also contribute to the UPR, collectively managing protein misfolding and restoring homeostasis, or, if stress persists, trigger cell death (Tabas and Ron, 2011)
10.4238/gmr.15028787 50 JiangN.LiZ.LuoY.JiangL.ZhangG.YangQ.et al (2021)
PubMed Staresinic, M., Sebecic, B., Patrlj, L., Jadrijevic, S., Suknaic, S., Perovic, D., Aralica, G., Zarkovic, N., Borovic, S., Srdjak, M., Hajdar, S., Kopljar, M., Batelja, L., Boban-Blagaic, A., Turcic, I., Amic, F., Ruenzi, E., Rucman, R., Seiwerth, S., Sikiric, P
