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Similarly, the highly anticipated EVOKE and EVOKE+ phase 3 trials of oral semaglutide in early Alzheimers disease reported in November 2025 that semaglutide failed to meet its primary endpoints : while it reduced several AD-related biomarkers by up to 10%, these changes did not translate into cognitive or functional benefit ( [72] )
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: L-carnitine
doi: 10.1038/s41591023-023441 84 NichollsSJBhattDLBuseJBPratoSDKahnSELincoffAMet al
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