Evolution of sodium-glucose co-transporter 2 inhibitors from a glucose-lowering drug to a pivotal therapeutic agent for cardio-renal-metabolic syndrome
a reduced form of GSH dimerizes to its oxidized form, glutathione disulfide GSSG(Owen & Butterfield, 2010), such that the ratio of GSH to GSSG gives information about the cells healthy response to OS
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Advances in fluid-based biomarkers (A, tau, neurofilament light chain), functional neuroimaging (PET, MRI), and genetic profiling (APOE status, transcriptomics) are enabling earlier diagnosis and more personalized treatment strategies