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The FDA considers you clinically obese, and GLP-1 medications are approved for your use regardless of whether you have any other health complications
Mechanistically, compound 25 disrupts the interaction between SKP1-SKP2 and thus abrogates SCF SKP2 ligase activity
Jumping to a high dose too quickly increases the risk of severe nausea, vomiting, and other GI side effects that can make the medication intolerable
However, you should still keep us informed about these changes because, as indicated by the list above, they can be clues to more involved health problems
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