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Clausen et al., 2020

Nature 639 , 10521059 (2025)

Brighten: Fantastic

Unlike mild GLP-1 side effects, these symptoms do not resolve with dietary changes and require immediate medical evaluation Core symptoms severe upper abdominal pain pain radiating to the back persistent nausea and vomiting abdominal tenderness fever rapid heart rate Severe warning signs inability to keep fluids down confusion or fainting jaundice breathing difficulty signs of dehydration or shock Pancreatitis is a medical emergency

The robust weight loss combined with a well-tolerated safety profile reinforces our confidence in the clinical development programme [of CT-388] as we advance to phase III trials" Dr Levi Garraway, PhD, Roches Chief Medical Officer and Head of Global Product Development, said: We are pleased to see such meaningful weight loss in people treated with CT-388