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FIGURE 8 Atherosclerosis, a chronic inflammatory disease, may be an ideal environment for the high viral replication capabilities of SARS-CoV-2 in human cells, enhancing hyper-inflammation secondary to immune system dysregulation (Figure 9) that leads to adverse outcomes, as shown in patients with cardiovascular risk factors (258, 259)

The result is a more firm and hydrated complexion with visibly fewer fine lines and wrinkles

However, the complexity and size of PLC has hindered its structural and functional analysis

While our previous study [32] identified gram-negative infections as a risk factor for NHO development, our study did not have enough power to investigate contributions from gram-positive versus gram-negative, nor contributions from viral or fungal pathogens

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