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Asparagine and glutamine residues can undergo deamidation, where the amide group is lost
Prog Neuropsychopharmacol Biol Psychiatry (2011) 35:74459
LIRA did not significantly alter soluble guanylyl cyclase or endothelial nitric oxide synthase (eNOS) mRNA levels, nor total myocardial eNOS protein expression
The timing of anxiety reductionoften occurring within weeks of starting therapysupports a mechanism beyond simple weight-loss-related confidence, pointing instead to direct neurobiological effects on emotional regulation pathways
The trial included 1,407 randomised adults with obesity
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