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Signs of a semaglutide overdose include unremitting nausea, headache, vomiting, and diarrhea
Glutathione binds with toxins in the liver, facilitating their excretion
Common side effects of semaglutide include nausea, vomiting, diarrhea, constipation, and abdominal pain
However, four fusions with a single point mutation (G2V, E15A, V19A and L26I) had potency at human GLP-1R similar to the target value and were investigated further for in vivo peptide stability and manufacturability
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