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(2025, December 9)

avoid injecting through clothing Use a swift, confident injection technique rather than hesitant, slow insertion Avoid injecting into areas with scarring, bruising, or active skin lesions Always use a new needle for each injection and follow local guidance for safe sharps disposal Post-injection care: Apply a cool compress (not ice directly on skin) to reduce swelling or discomfort Avoid rubbing or massaging the injection site immediately afterwards Wear loose-fitting clothing to minimise irritation For generalised burning or itching: Emollients and moisturisers : Regular application of fragrance-free, hypoallergenic moisturisers can soothe dry or irritated skin Antihistamines : Over-the-counter oral antihistamines (e.g., cetirizine, loratadine) may provide relief if itching is prominent

Sipping water between meals rather than during them is a commonly recommended adjustment

The trial validates an oral maintenance strategy following successful injectable-led weight loss, promises to improve patient convenience and adherence through a simple daily pill, and does so with a reassuring safety profile

MET-233i, a monthly dosing, ultra-long acting, subcutaneously injectable amylin analog candidate being evaluated as monotherapy and in combination with MET-097i in a Phase I trial