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There is significant precedence for such a loop-mediated catalytic mechanism that we observe here in CstB

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Its involved in detoxification, immune function, cellular repair, and nearly every major disease process researchers have studied

A.et al (2022)

Furthermore, studies utilizing time-resolved cryo-EM have elucidated the activated state of homomeric GluK2 in complex with Glu and PAMs BPAM and plant lectin Concanavalin A (ConA) (Zhou et al., 2025) and regulation by partial agonist domoate (Segura-Covarrubias et al., 2025