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For example, rat TDSCs treated with IGF-1 (1, 10, and 100 ng/mL) for 28 days exhibited the increased expression of tendon-specific marker (SCX) and significantly decreased expression of chondrogenic and osteogenic marker (collagen type II) (Holladay et al., 2016)

People who are otherwise healthy may be less willing to accept these potentially serious adverse events." GLP-1 agonists were originally developed for managing Type 2 diabetes, but exploded in popularity over the past decade as an off-label weight-loss tool, reaching approximately 40 million prescriptions in the U.S

The peptide consists of nine amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) and is found in both the brain and peripheral tissues

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