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Celecoxib alleviates the DSS-induced ulcerative colitis in mice by enhancing intestinal barrier function, inhibiting ferroptosis and suppressing apoptosis
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Women of childbearing age should undergo pregnancy testing before use and use contraception during treatment
That is, biologics/small molecule agent combination therapy, to the extent that it reduces both immunogenicity and a high inflammatory burden, has the potential to minimize steroid exposure, induce remission, and avoid colectomy by facilitating a safe transition to maintenance therapy
These were predominantly dose-dependent and most prominent during dose escalation
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